Which therapy is used in the treatment of tuberculosis?

The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol. You may begin to feel better only a few weeks after starting to take the drugs but treating TB takes much longer than other bacterial infections.

WHO recommended TB treatment?

The standardized regimens for anti-TB treatment recommended by WHO include five essential medicines designated as “first line”: isoniazid (H), rifampicin (R), pyrazinamide (Z), ethambutol (E) and streptomycin (S). Table 2.1 shows the recommended doses for adults and children.

Which is the rational drug therapy for tuberculosis?

Fluoroquinolones (FQs) have the potential to become an important component of a future TB treatment regimen, and drugs like moxifloxacin, ofloxacin and gatifloxacin are currently being evaluated in phase III clinical trials. The introduction of these agents could greatly influence global TB control efforts.

What is the first line drug for TB?

Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are: isoniazid (INH) rifampin (RIF) ethambutol (EMB)

Why is multiple drug therapy used for tuberculosis?

When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others. The standard of care for initiating treatment of TB disease is four-drug therapy.

Why is TB treated with 4 drugs?

What is the second-line treatment of TB?

Grouping of drugs Drugs line category
Group 1 Isoniazid, rifampicin, ethambutol, pyrazinamide
Second-line anti-tuberculosis drugs
Group 2 Moxifloxacin, high dose levofloxacin (fluoroquinolones)
Group 3 Linezolid, delamanid, bedaquiline (newer drugs with increased evidence)

Is TB resistant to antibiotics?

The bacteria that cause tuberculosis (TB) can develop resistance to the antimicrobial drugs used to cure the disease. Multidrug-resistant TB (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the 2 most powerful anti-TB drugs.

What is second line drugs for TB?

Second line drugs are the TB drugs that are used for the treatment of drug resistant TB. The second line drugs include levofloxacin, moxifloxacin, bedaquiline, delamanid and linezolid. There is also pretomanid which is a new second line drug recommended in 2019 for the treatment of drug resistant TB.

What is first-line treatment for TB?

How are TB patients monitored during their treatment?

Patients collecting more drugs for their TB treatment by presenting the empty packages from the last week. All patients receiving TB treatment should be monitored during their treatment to assess their response to the drug treatment. Regular monitoring also helps to ensure that patients complete their treatment.

Which is the first line of treatment for TB?

Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are: 1 isoniazid (INH) 2 rifampin (RIF) 3 ethambutol (EMB) 4 pyrazinamide (PZA)

Are there any new drugs to treat tuberculosis?

Treatment of multiple drug–resistant tuberculosis remains a difficult problem requiring lengthy treatment with toxic drugs. However, shortened regimens show promise, and two new drugs, bedaquiline and delamanid, have demonstrated effectiveness in preliminary studies and are being used for extensively drug-resistant tuberculosis. Show All

How long does it take to treat drug susceptible pulmonary TB?

For new patients with presumed drug susceptible pulmonary TB, the World Health Organisation (WHO) recommends that they should have six months of treatment. This consists of a two month intensive phase followed by a four month continuation phase.