Contents
What is the success rate of exemestane?
As first-line treatment, once daily exemestane 25 mg elicited objective and overall success rates of 42 and 58%, compared with 16 and 31% for once daily tamoxifen 20 mg. Exemestane was generally well tolerated in clinical trials at once daily dosages up to 600 mg.
What are the long term side effects of exemestane?
Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
How long should you stay on exemestane?
This will depend on your individual circumstances, but exemestane is usually taken for five to ten years. Some people start taking exemestane after a few years of taking the hormone therapy drug tamoxifen.
How long should I stay on Aromasin?
Official Answer. Most women take Aromasin for two to three years. Doctors may recommend some women take it for longer. Aromasin is usually given after two to three years of treatment with tamoxifen, for a total of five years of continuous hormonal treatment.
Which is better tamoxifen or exemestane?
Overall, 5-year DFS was significantly improved among patients who received ovarian suppression with exemestane compared with those who received tamoxifen (91.1% vs. 87.3%; HR=0.72; 95% CI, 0.60-0.86). Exemestane was also associated with superior 5-year breast cancer-free interval (92.8% vs.
Which is better anastrozole or exemestane?
The steroidal inhibitor exemestane is partially non–cross-resistant with nonsteroidal aromatase inhibitors and is a mild androgen and could prove superior to anastrozole regarding efficacy and toxicity, specifically with less bone loss.
Can I take vitamin D with exemestane?
No interactions were found between exemestane and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can Aromasin cause liver damage?
Cases of acute liver failure have been reported in women on exemestane therapy, but the relationship of the injury to the aromatase inhibitor has not been well defined.
Is Aromasin better than letrozole?
Researchers that compared Aromasin and Femara used in early breast cancer found that the two drugs worked equally well. With Aromasin, 88% of women lived for at least 5 years without their breast cancer returning, while 89.4% of women taking Femara lived for at least 5 years without their breast cancer returning.
What’s better Aromasin or Arimidex?
One study published in The Lancet Oncology compared anastrozole, exemestane, and letrozole. The study found that these aromatase inhibitors were similarly effective for treating hormone receptor-positive breast cancer.
Is exemestane a hormone therapy?
Drug Type: Exemestane is an anti-cancer hormone therapy. It is classified as an “aromatase inhibitor.” (For more detail see “How Exemestane Works” below).
What is the difference between Aromasin and exemestane?
Aromasin is the brand name for exemestane. It was FDA approved in 1999, and it is used to treat hormone receptor-positive receptor early breast cancer in postmenopausal women who have already used tamoxifen for two to three years. Aromasin is available as a 25 mg tablet taken once daily after a meal.
Which is the best brand name for Aromasin?
Aromasin is the brand name of a steroidal aromatase inhibitor (AI) Exemestane, and it is considered the most modern and best AI available. This brand name is patented tightly by the big pharmaceutical company Upjohn. Aromasin – 25 mg.
How is Aromasin used to treat breast cancer?
Aromasin is a very strong and very potent steroidal aromatase inhibitor of the suicidal type, and information within the packaging in prescription Aromasin describes the ability for Aromasin to reduce Estrogen levels by 85%, as evidenced by studies on breast cancer patients [1].
This is very different from Aromasin (Exemestane), which is a steroidal and suicidal aromatase inhibitor that acts as a mechanism-based steroidal inhibitor that mimics the substrate, is converted by the enzyme to a reactive intermediate, and results in the inactivation of the aromatase enzyme[3].
When to use Aromasin in a steroid cycle?
Use in bodybuilding. For this reason, bodybuilders will use an aromatase inhibitor during their steroid cycles to help control estrogen. As long as the user does not overdose, aromasin is a very mild AI, and estrogen levels do not become too low, which is a good thing because males still need some estrogen.