What is a Collagenoma?

Collagenoma is a type of connective tissue nevi, a rare hamartomatous malformation characterized by the predominant proliferation of normal collagen fibers and normal, decreased, or increased elastic fibers.

What is eruptive collagenoma?

Eruptive collagenomas are non familial connective tissue nevi of unknown etiology presented with an abrupt onset. While most cases are reported in young adults, there is a paucity of literature in children.

How do you treat Collagenoma?

The only real options for these lesions is excision if removal is needed or desired. Treatment with laser ablation has been described. Cosmetic or symptomatic improvement by partial removal or shaving them flat could be considered to reduce the overall size.

What is epidermal nevus?

An epidermal nevus (plural: nevi) is an abnormal, noncancerous (benign) patch of skin caused by an overgrowth of cells in the outermost layer of skin (epidermis ). Epidermal nevi are typically seen at birth or develop in early childhood. Affected individuals have one or more nevi that vary in size.

What causes facial Angiofibromas?

What causes angiofibromas? Angiofibromas are caused by a local overgrowth of collagen, fibroblasts, and blood vessels. In tuberous sclerosis, mutations are present in tuberous sclerosis complex 1 (TSC1), which encodes the protein hamartin, and tuberous sclerosis complex 2 (TSC2) which encodes the protein tuberin.

What causes connective tissue nevus?

A connective tissue naevus (American spelling nevus) is an uncommon skin lesion that occurs when the deeper layers of the skin do not develop correctly or the components of these layers occur in the wrong proportion. There may be too much collagen; this is called a collagenoma.

What is Beckers nevus?

Becker’s nevus is a non-cancerous, large, brown birthmark occurring mostly in males. It can be present at birth, but is usually first noticed around puberty. It typically occurs on one shoulder and upper trunk but occasionally occurs elsewhere on the body.

What causes nevus?

These marks are thought to be caused by a localized increase in melanocytes as a baby grows in the womb. Melanocytes are the skin cells that produce melanin, which gives skin its color. A nevus has an increased amount of melanocytes. The condition is thought to be caused by a gene defect.

How do you treat angiofibromas on face?

Current treatment options for facial angiofibromas include destructive approaches such as dermabrasion, surgical excision, and laser therapy. A more targeted therapeutic approach is needed because current therapies are not effective in preventing early lesions and therefore may have less than satisfactory outcomes.

How do you get rid of angiofibromas?

shave or punch biopsy (removing part of the angiofibroma) electrosurgery (using an electrical device to destroy the angiofibroma) topical application of sirolimus (also called rapamycin which is an mTOR inhibitor) for multiple angiofibromas associated with tuberous sclerosis complex.

Is a nevus a hamartoma?

Connective tissue nevi are hamartomas that typically present at birth or during early childhood as firm, flesh-colored papules, nodules, or plaques. They may be solitary or multiple and occur in a grouped, linear, or irregular distribution.

What is Nevus of Ito?

Nevus of Ito is a unilateral, benign, dermal melanocytosis that presents as a darkly pigmented patch on the side of the neck and shoulder in the distribution of the posterior supraclavicular and lateral cutaneous brachial nerves.

Is the term insanity a medical or legal term?

[in-san´ĭ-te] a medically obsolete term for mental derangement or disorder. Insanity is now a purely legal term, denoting a condition due to which a person lacks criminal responsibility for a crime and therefore cannot be convicted of it.

Where does storiform collagenoma occur in the body?

Storiform collagenoma is a rare tumor, which originates from the proliferation of fibroblasts that show increased production of type-I collagen. It is usually found in the face, neck and extremities, but it can also appear in the trunk, scalp and, less frequently, in the oral mucosa and the nail bed …

What are some facts and facts about insanity?

The straight facts about insanity are these: it has been in use in English since the late 16th century, for the first two hundred years or so carrying only the literal meaning “the condition of being mentally deranged.” In the 19th century it began to take on a looser sense, “extreme folly or unreasonableness.”

What’s the definition of insanity according to Albert Einstein?

An oft-quoted bon mot (frequently attributed to Albert Einstein, Benjamin Franklin, or a number of other people who probably never said it) is that insanity may be defined as “doing the same thing over and over and expecting different results.” While the job of lexicographers might be easier if they were allowed to use witty sayings instead of