How does diabetes lead to hypertension?

“Over time, diabetes damages the small blood vessels in your body, causing the walls of the blood vessels to stiffen. This increases pressure, which leads to high blood pressure.” The combination of high blood pressure and type 2 diabetes can greatly increase your risk of having a heart attack or stroke.

What causes diabetic angiopathy?

The main cause of diabetic angiopathy is high blood sugar. If sugar is present in excessive amounts in the blood it can damage cells and tissues. The cells that line the arteries are damaged and the smooth layer of the cell wall called endothelium is compromised.

How does diabetes cause damage to blood vessels?

Excess blood sugar decreases the elasticity of blood vessels and causes them to narrow, impeding blood flow. This can lead to a reduced supply of blood and oxygen, increasing the risk of high blood pressure and damage to large and small blood vessels.

How does insulin affect blood pressure?

Insulin can increase blood pressure via several mechanisms: increased renal sodium reabsorption, activation of the sympathetic nervous system, alteration of transmembrane ion transport, and hypertrophy of resistance vessels.

Does diabetes cause low blood pressure?

Parathyroid disease, adrenal insufficiency (Addison’s disease), low blood sugar (hypoglycemia) and, in some cases, diabetes can trigger low blood pressure.

Why does diabetes cause gangrene?

Diabetes. People with diabetes have an increased risk of developing gangrene. This is because the high blood sugar levels associated with the condition can damage your nerves, particularly those in your feet, which can make it easy to injure yourself without realising.

What is angiopathy mean?

Medical Definition of angiopathy : a disease of the blood or lymph vessels.

What is an angiopathy?

Angiopathy: Disease of the arteries, veins, and capillaries. There are two types of angiopathy: microangiopathy and macroangiopathy. In microangiopathy, the walls of small blood vessels become so thick and weak that they bleed, leak protein, and slow the flow of blood.

What is the difference between microangiopathy and Macroangiopathy?

Macroangiopathy is characterized by advanced atherosclerosis in coronary, carotid and peripheral arteries, which increase the risk of myocardial infarction, stroke [2] and development of diabetic foot, while microangiopathy is histologically characterized by a progressive glomerulosclerosis, arteriolosclerosis and …

How does hypertension damage blood vessels?

High blood pressure can damage your arteries by making them less elastic, which decreases the flow of blood and oxygen to your heart and leads to heart disease. In addition, decreased blood flow to the heart can cause: Chest pain, also called angina.

Does insulin damage blood vessels?

By studying blood vessel tissue from 674 patients, a research team has discovered how insulin contributes to the dysfunction of blood vessels in atherosclerosis, one of the most common chronic health conditions worldwide.

What kind of disease is diabetic peripheral angiopathy?

Diabetic angiopathy is a kind of complication, which is common among people that suffer from diabetes mellitus. In the course of the disease sides of blood vessels and capillary tubes in particular are decaying and the blood stasis is suffering very much. Diabetic angiopathy is divided into two types of the diseases: micro- and macro-angiopathy.

How is endothelial dysfunction related to diabetic angiopathy?

Conclusions: Endothelial dysfunction plays a key role in the pathogenesis of diabetic angiopathy in man. The biochemical basis of endothelial dysfunction in diabetic man, however, has yet to be fully elucidated. Time for primary review 27 days.

What is the presence of nephropathy in diabetes?

Both in insulin-dependent (IDDM) and in non-insulin-dependent diabetes (NIDDM), the presence of nephropathy, even in its early stages (so-called ‘microalbuminuria’), identifies a group of patients at very high risk of developing severe complications (i.e., proliferative retinopathy, renal insufficiency, and cardiovascular disease) [1, 2].