Can misoprostol be repeated 3 times?

The ACOG states that one repeat dose may be administered no earlier than 3 h after the first dose and typically within 7 days, if there is no response to the first dose (ACOG, 2015).

How many doses of misoprostol is safe?

The recommended adult oral dose of Cytotec for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily with food. If this dose cannot be tolerated, a dose of 100 mcg can be used.

How many misoprostol can I take for 6 weeks?

Termination of pregnancies of <6 weeks gestation with a single dose of 800 microg of vaginal misoprostol. Contraception.

How often can misoprostol be given?

When used for cervical ripening, misoprostol can be administered orally, sublingually, or vaginally, although there is more evidence for vaginal regimens. A commonly used dose is 25 µg administered vaginally every 4 hours as needed, with a maximum dose of 150 µg.

Can I insert 2 misoprostol?

Step 1: Insert only two (not four) 200-mcg tablets in the vagina. The termination of second-trimester pregnancies requires lower doses of misoprostol because the uterus is more sensitive to the drug. Overdoses at this stage of pregnancy are dangerous.

How many misoprostol do I insert?

Participants will insert four misoprostol tablets (total of 800 micrograms) deeply into the vagina with their fingers. Participants will place two tablets of misoprostol between their gum and cheek on each side (total 800 micrograms), then swish and swallow the remnants after 30 minutes.

How far should you insert misoprostol?

The most ideal place is to push the tablets behind the cervix at the top of the vagina. As long as you push them as high in the vagina as you can, they will work. Some women will place all 4 tablets at once. Some women will place them one at a time.

What is the time gap between mifepristone and misoprostol?

Background: The recommended time interval between mifepristone and misoprostol in medical second trimester termination of pregnancy (TOP) has been 36-48 h. However, a more flexible interval would be of value.

How long does it take for misoprostol to dissolve vaginally?

Lie down for about 30 minutes after you insert the misoprostol tablets to allow the tablets to dissolve. If you notice the tablets falling out, you may push them back in again or call us for instructions on what to do. 7.

Can misoprostol cause damage to the womb?

Misoprostol can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use misoprostol if you are pregnant.

How long do I have to wait to take misoprostol?

The FDA label recommends misoprostol 800 mcg buccally from 24-48 hours after mifepristone. An alternate evidence-based route is vaginal misoprostol administration, allowing a window of 6-72 hours after mifepristone.

Can I take misoprostol orally with water?

To take the misoprostol, place the tablets between your cheeks and gums and allow to dissolve for 30 minutes. If there are still some tablet pieces left in your mouth after 30 minutes, swallow them with a glass of water. Plan to rest for 3 hours after taking the misoprostol tablets.

Which is the best route of misoprostol administration?

Pharmacokinetics Routes of misoprostol administration include oral, vaginal, sublingual, buccal, or rectal.

What’s the success rate of misoprostol in pregnancy?

For early pregnancy failure, the most commonly used regimen is a single dose of 800 µg of vaginal misoprostol. The success rate is approximately 85% as long as at least 7 to 14 days is allowed for completion of expulsion and a second dose of misoprostol is considered for initial failures.

When did the FDA approve misoprostol for abortion?

In 2000, the FDA approved medication abortion using 600 mg of oral mifepristone, a progesterone antagonist, with 400 µg of oral misoprostol 48 hours later for pregnancies up to 49 days of gestation.

Why are there remnants of misoprostol tablets?

The misoprostol tablet was not manufactured and developed for use by routes other than oral administration. It is not uncommon to identify remnants of the tablets hours after vaginal administration, indicating that absorption is variable and incomplete.