Contents
What is benzocaine made from?
Benzocaine is a chemical compound derived from para-aminobenzoic acid and ethanol. It is a white, odorless, crystalline powder. It acts on neuronal membranes and blocks nerve signals in the body. Its numbing effects are temporary.
Why is absolute ethanol used in the synthesis of benzocaine?
Benzocaine is soluble in Ethanol, Methanol and Diethyl Ether. But it is not very soluble in water. Having water in the solution would decrease the solubility and would create a lot of hassle later. Using 95 % ethanol would reduce the yield of benzocaine.
What is the role of h2so4 in ethyl p aminobenzoate benzocaine from P aminobenzoic acid?
The reaction mixture should dissolve completely in the water, since the ethyl p-aminobenzoate is in the form of the hydrogen salt. At this point the sulfuric acid is completely neutralized, and the ethyl p-aminobenzoate precipitates.
What’s novocaine made from?
Novocain, procaine hydrochloride, is benzoic acid, 4-amino-, 2-(diethylamino) ethyl ester, monohydrochloride, the ester of diethylaminoethanol and aminobenzoic acid, with the following structural formula: It is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol.
How is benzocaine synthesised with a condenser?
Synthesising Benzocaine via Reflux with a Condenser. In the experiment, the reactants carboxylic acid (4-aminobenzoic acid) and ethanol were used to synthesize esters (benzocaine, isopropyl 4-aminobenzoic acid) and water molecules as leaving group. The Fischer Esterification reaction mainly functions at pH less than 8.
How is benzocaine prepared as a local anesthetic?
1 SYNTHESIS OF BENZOCAINE 1 1 Synthesis of Benzocaine 1.1 Method [4] I synthesized a local anesthetic called Benzocaine (Fig. 1 on page i). Benzocaine was prepared in this experiment by the direct esterification of p– Aminobenzoic acid with absolute ethanol.
How is benzocaine produced in a reflux reaction?
The intention of the experiment was to synthesise benzocaine, an ester, from 4-aminobenzoic acid, a carboxylic acid, by Fischer Esterification. The mechanism in figure 1 was to combined 4-aminobenzoic acid and ethanol in a reflux reaction with the addition of sulphuric acid as a catalyst to produce the product.
What was the aim of the benzocaine experiment?
Synthesis and characterisation of benzocaine experiment practical report Aim: The experiment was to synthesise benzocaine via reflux with a condenser and was characterised by examining at the infra-red spectrum and chemical shifts of NMR.