What is Atgam?
Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.
What is thymoglobulin used for?
Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a purified polyclonal immunoglobulin used for prevention and treatment of acute rejection (AR) following renal transplantation. Thymoglobulin is mostly used for treating vascular, steroid-resistant and antibody-mediated rejection.
How does ATG treatment work?
ATG works by killing specific cells in your immune system called T-lymphocytes — the cells that are attacking bone marrow stem cells in aplastic anemia. This allows an aplastic anemia patient’s bone marrow to rebuild its supply of bone marrow stem cells, causing blood counts to go up.
How much does Antithymocyte globulin cost?
The costs for basiliximab and antithymocyte globulin were calculated based on average wholesale prices (AWP). The price of basiliximab was $1224 per dose and the price of antithymocyte globulin was $262.24 per 250 mg ampoule .
How do you administer an Atgam?
Administer the first dose within 24 hours before or after the transplant. Treatment of Rejection: The first dose of ATGAM can be delayed until the diagnosis of the first rejection episode. The recommended dose is 10 to 15 mg/kg daily for 14 days. Additional alternate-day therapy up to a total of 21 doses can be given.
How do you infuse Atgam?
Preparation And Administration Dilute ATGAM for intravenous infusion in an inverted bottle of sterile vehicle so the undiluted ATGAM does not contact the air inside. Add the total daily dose of ATGAM to the sterile vehicle (see Compatibility and Stability). Do not exceed a concentration of 4 mg of ATGAM per mL.
When do you take THYMOGLOBULIN?
The recommended dosage of THYMOGLOBULIN for prophylaxis of acute rejection in patients receiving a kidney transplant is 1.5 mg/kg of body weight administered daily with the first dose initiated prior to reperfusion of the donor kidney. The usual duration of administration is 4 to 7 days.
What is ATG in transplant?
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia.
Is Atgam a monoclonal antibody?
Antilymphocyte antibodies include polyclonal preparations, such as equine antithymocyte globulin (ATGAM) and rabbit antithymocyte globulin (Thymoglobulin), and the monoclonal antibody preparations muromonab-CD3 (OKT3) and anti-CD52 (Alemtuzumab).
What does anti-thymocyte globulin?
Are anti-rejection drugs expensive?
Antirejection medications are critical in maintaining the transplanted organ. During the first year after transplant, anti-rejection drugs can cost from $1,500 to 1,800 per month. After the first year, the costs are reduced significantly.
Does Medicare pay for transplant drugs?
Medicare may cover transplant surgery as a hospital inpatient service under Part A. Medicare covers immunosuppressive drugs if the transplant was covered by Medicare or an employer or union group health plan was required to pay before Medicare paid for the transplant.
What do you need to know about Atgam?
ATGAM ® (lymphocyte immune globulin, anti-thymocyte globulin [equine] sterile solution) This product information is intended only for residents of the United States. for Health Care Professionals: ATGAM U.S. Physician Prescribing Information.
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How is Atgam used to treat MDS patients?
To prevent or lessen the effects of graft versus host disease (GvHD) before or after a stem cell transplant. To help bone marrow make new blood cells in patients with MDS. Your healthcare team will decide if Atgam is right for your treatment plan.
What are the active ingredients in Atgam 5 ml ampoule?
The active ingredient in ATGAM is equine antithymocyte immunoglobulin. There are 250 mg equine antithymocyte immunoglobulin in the 5 mL ampoule. Other ingredients are glycine, Water for Injections, sodium hydroxide and hydrochloric acid. ATGAM does not contain any preservatives.