What do GH secreting tumors cause?

Also called GH, the growth hormone secreted by these tumors triggers the liver to produce insulin-like growth factor 1, or IGF-1. IGF-1 is involved in bone and tissue growth, metabolism, and other processes of the body. When the body produces too much IGF-1, it leads to a range of symptoms known as acromegaly.

What is ACTH tumor?

ACTH-secreting pituitary adenoma is a condition characterized by elevated levels of a hormone called cortisol secreted by a tumor in the pituitary gland.

What happens if there is a tumor on the pituitary gland?

Large tumors put pressure on the area around the pituitary gland and cause: Headaches. Problems with eyesight, especially loss of peripheral vision (what you can see off to the side even as you look straight ahead) and double vision.

What is secreting tumor?

A rare tumor that makes the hormone adrenocorticotropin (ACTH), which causes the adrenal glands to make too much cortisol. Adrenocorticotropic-secreting tumors can lead to Cushing syndrome.

What is Hypopituitary?

Hypopituitarism is a rare disorder in which your pituitary gland fails to produce one or more hormones, or doesn’t produce enough hormones. The pituitary gland is a kidney-bean-sized gland situated at the base of your brain.

What is Panhypopit?

Listen to pronunciation. (pan-HY-poh-pih-TOO-ih-tuh-rih-zum) A rare condition in which the pituitary gland stops making most or all hormones. Pituitary hormones help control the way many parts of the body work.

What is a hormone secreting tumor?

Carcinoid tumors are noncancerous (benign) or cancerous (malignant) growths that sometimes produce excessive amounts of hormone-like substances (such as serotonin), resulting in the carcinoid syndrome. Carcinoid syndrome is a group of specific symptoms that occur as a result of these hormones.

What is ectopic ACTH secretion?

Ectopic ACTH syndrome represents a cancer-induced amplification of a property [proopiomelanocortin (POMC) peptides production] normally present in the cells from which the cancer originated but with aberrant posttranslational processing of POMC resulting in a greatly elevated secretion of ACTH precursors.

Is pituitary tumor curable?

Most pituitary tumors are curable. If a pituitary tumor is diagnosed early, the outlook for recovery is usually excellent. However, if tumors grow large enough, or grow rapidly, they are more likely to cause problems and will be more difficult to treat.

What kind of tumors can secrete ACTH?

Small cell tumors of the lung, tumors of the thymus gland, islet cell tumors of the pancreas, and medullary carcinoma of the thyroid are tumors that can secrete ACTH, although this occurs rarely.

What causes ACTH secreting in the pituitary adenoma?

Some cases are caused by somatic mutations in the AIP and the GNAS genes . Rarely, an ACTH-secreting pituitary adenoma can be inherited, either as an isolated condition or as part of a genetic syndrome (such as multiple endocrine neoplasia type 1 (MEN1) and familial isolated pituitary adenoma ), but most cases are sporadic. [1]

What causes high ACTH levels in the petrosal sample?

If a tumor is present in the pituitary gland, the results will show higher levels of ACTH in the petrosal sample only. If a tumor located elsewhere in the body is raising the level of ACTH in the body, then the ACTH levels will be high but around the same level in both samples. At Memorial Sloan Kettering,…

Can a tumor in the pancreas secrete cortisol?

The patient is presenting with Cushing syndrome, secondary to ACTH production by her pancreas lesion (likely a neuroendocrine tumor), which leads to increased cortisol production by the adrenal glands. Pancreatic tumors do not themselves secrete cortisol.