Contents
What causes APMPPE?
The exact etiology of APMPPE is unknown, however some believe that it is secondary to a delayed-type hypersensitivity-induced occlusive vasculitis. Gass originally posited that inflammation of the outer retina and RPE causes the APMPPE phenotype.
What is APMPPE eye disease?
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare eye disorder of unknown (idiopathic) cause. The disorder is characterized by the impairment of central vision in one eye (unilateral) but, within a few days, the second eye may also become affected (bilateral).
What is retinal pigment epitheliopathy?
Epitheliopathy or acute posterior multifocal placoid pigment epitheliopathy (APMPPE) refers to an acquired inflammatory illness affecting the retinal pigment epithelium. It can affect one or both eyes, and is characterized by multiple yellowish white or light-colored lesions that form in the retina.
What are white dot syndromes?
The white dot syndromes are a group of idiopathic multifocal inflammatory conditions involving the retina and the choroid. They are characterized by the appearance of white dots in the fundus.
What is relentless Placoid Chorioretinitis?
Relentless Placoid Chorioretinitis (RPC), also known as Ampiginous Choroiditis, is a rare, bilateral disease of the retinal pigment epithelium (RPE) and choroid that is considered an atypical variant of serpiginous choroiditis (SC) and acute posterior multifocal placoid pigment epitheliopathy (APMPPE)[1].
What is Serpiginous Choroiditis?
Serpiginous Choroiditis is a rare recurrent eye disorder characterized by irregularly shaped (serpiginous) lesions involving two layers of the eye surface (the retinal pigment epithelium and the choriocapillaris). No symptoms are apparent unless a specific area of the retina (macula) is damaged.
How long does Mewds last?
MEWDS is a self limited disease with excellent visual recovery within 2-10 weeks. However residual symptoms including photopsia may persist for months.
What is the meaning of photopsia?
Photopsias are sometimes referred to as eye floaters or flashes. They’re luminous objects which appear in the vision of either one or both eyes. They can disappear as quickly as they appear or they can be permanent.
What is RP that causes blindness?
Often diagnosed in childhood or adolescence, retinitis pigmentosa (RP) is an inherited retinal disease causing progressive loss of night and peripheral vision. The condition often leads to legal and sometimes complete blindness.
What does white dot syndrome look like?
Typically seen in young, otherwise healthy adults, the white dot syndromes most often present with symptoms of photopsia, floaters, decreased night vision, blurred vision, and visual field loss.
Is Serpiginous Choroiditis an autoimmune disease?
The cause of serpiginous choroiditis is unknown. Speculation exists regarding an association with exposure to various toxic compounds and/or infectious agents. Some researchers believe the condition is related to an organ -specific autoimmune inflammatory process.
Is multifocal Choroiditis rare?
Multifocal choroiditis (MFC) with panuveitis is a rare, recurrent white dot syndrome affecting myopic women in their third to fourth decades. Symptoms include blurred vision, photopsia, or scotoma [1].