How much does TC-99 cost?
The average cost of an individual patient dose at the point of dispensing of Tc-99m is estimated to be around 21 USD, which is small relative to the broader provider payments for the diagnostic service, the DRG or the global budget.
How much is technetium worth?
Until 1960, technetium was available only in small amounts and the price was as high as $2800/g. It is now commercially available to holders of O.R.N.L. permits at a price of $60/g.
Where is Tc-99m obtained?
Tc-99m is obtained from technetium generators through a process referred to as elution. Tc-99m pertechnetate (TcO4–) is produced on the alumina column as Mo-99 decays. A saline solution (0.9% NaCl) is used to wash the pertechnetate from the column.
How does a technetium-99m generator work?
Tc-99m is radioactive because one or more of the protons and neutrons in its nucleus is in an excited state. Tc-99m decays into Tc-99 with a half-life of six hours and this makes it particularly well suited to use in the body: after one day (four half-lives) only 6.3% of the initial Tc-99m remains.
Is TC 99 expensive?
Price quotes are provided for individual Tc-99m pertechnetate doses and for bulk Tc-99m sodium pertechnetate. Most of the prices fall in the range from $0.28 to $0.45 per mCi, but two prices were much higher, about $0.90 per mCi.
What is the difference between technetium 99m and technetium-99?
Technetium-99 is produced during nuclear reactor operation, and is a byproduct of nuclear weapons explosions. Technetium-99m is a short-lived form of Tc-99 that is used as a medical diagnostic tool. It has a short half-life (6 hours) and does not remain in the body or the environment for long.
How much does technetium cost per gram?
Technetium is a silvery-gray metal that tarnishes slowly in moist air. Until 1960, technetium was available only in small amounts and the price was as high as $2800/g. It is now commercially available to holders of O.R.N.L. permits at a price of $60/g.
Who discovered technetium?
Claims in the 1920s to have found this element, or at least to have observed its spectrum, cannot be entirely discounted. Technetium was discovered by Emilio Segrè in 1937 in Italy.
Is technetium-99m a radiopharmaceutical?
Technetium-99m (99mTc) is a synthetic radioisotope that is used worldwide to produce radiopharmaceuticals that are mainly used for diagnostic purposes in nuclear medicines. The purity of the final radiopharmaceutical (99mTc-R) can be confirmed by applying chromatographic methods.
How do you get 99 Molybdenum?
Mo-99 is produced in the uranium-bearing targets by irradiating them with thermal neutrons. Some of the U-235 nuclei absorb these neutrons, which can cause them to fission. The fission of the U-235 nucleus produces two but sometimes three lower-mass nuclei referred to as fission fragments.
What is Mo generator?
The molybdenum-technetium generator system is based on the principle that the shorter-lived radioactive daughter nuclide (99mTc) can be easily and repeatedly isolated from its longer-lived parent radionuclide (99Mo). Through this process the daughter radionuclides isolated free of contamination from the parent.
How is Mo99 breakthrough calculated?
Radiopharmaceutical Preparation The Morning Elution
- 1000 mCi was eluted from the Tc99m/Mo99 generator in 10.0 mL.
- The Moly breakthrough was 5.7 μCi.
- To calculate Mo99 breakthrough apply the above formula.
- Applying our numbers to determine Moly breakthrough: 5.7 μCi/1000 mCi = 0.0057 μCi/mCi.